anti-[SW|sigma factor] to [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB], protein serine kinase, phosphorylates [protein|AC64DA463250A090A62E50901EFE653C8F963872|RsbV]
function
control of [protein|search|SigB ]activity
product
anti-[SW|sigma factor], protein serine kinase
Genomic Context
categories
[category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.2|Protein kinases][category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.1|Sigma factors and their control] → [category|SW 3.4.1.2|Control of sigma factors][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.1|General stress proteins (controlled by SigB)]Gene
Coordinates
522,414 522,896
The protein
Catalyzed reaction/ biological activity
phosphorylation of [protein|AC64DA463250A090A62E50901EFE653C8F963872|RsbV]negative regulator (by binding) of [protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]Protein family
anti-sigma-factor family (according to Swiss-Prot)Structure
[PDB|1TIL] ([protein|C8B867758330355F44C63CC284DC7AA3061FB9F1|SpoIIAB], 32% identity) [pubmed|15236958]Expression and Regulation
Operons
genes
[gene|621357D1FB6AC1B0499732EFE226F982B26CE34E|rsbR]-[gene|841CE7FCA4E84445830CA18F9856F6F30014E3BB|rsbS]-[gene|ADC52A22950736A0435AEEEC43F7407878786A81|rsbT]-[gene|0B8381D2C724DAA724E4AFC67000F12AD112D13D|rsbU]-[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
description
[Pubmed|8002610]
sigma factors
[protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|8002610], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon][protein|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB]: sigma factor, [Pubmed|11544224], in [regulon|580011DE5DC40EC9E7E0512791D328FAA010DCB8|SigB regulon]regulatory mechanism
[protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|20454630], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]regulation
''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]view in new tabgenes
[gene|AC64DA463250A090A62E50901EFE653C8F963872|rsbV]-[gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]-[gene|580011DE5DC40EC9E7E0512791D328FAA010DCB8|sigB]-[gene|8536803BDFB58D43C52961931F609933E49E989D|rsbX]
description
[Pubmed|2170324]
regulation
''[protein|search|rsbV]:'' induced by stress ([protein|search|SigB]) [Pubmed|11544224]view in new tabBiological materials
Mutant
BKE04720 ([gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE04720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCGATGTAATCAGCATTAT, downstream forward: _UP4_TATTTAAATGGGGAGCGAGTBKK04720 ([gene|5AF5F199C5D92E13DE1C56E28948A557E3954CBF|rsbW]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK04720 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TTCGATGTAATCAGCATTAT, downstream forward: _UP4_TATTTAAATGGGGAGCGAGTlabs
[SW|Bill Haldenwang], San Antonio, USA[SW|Chet Price], Davis, USA [http://foodscience.ucdavis.edu/price_lab/pricelab.html homepage]References
8682789,8144446,8002610,8682769,11591687,8955331,8460143,8808936,8824586,8764398,7601843,15342585,12270815,23524614,11544224,23407164,21979936,25278935,27977677,15236958 
